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  Model:  Alertme   you are here: research grants > r01 > dk > biological > mechanism > biological mechanism of familial focal segmental glomerulosclerosis-1 research topics actinin microfilament proteins actins amino acid substitution protein binding intercellular junctions chemical models ultracentrifugation tertiary protein structure binding sites kidney glomerulus cell membrane permeability viscosity calcium binding proteins mutant strains mice mutagenesis electrostatics genetic screening calcium signaling x ray diffraction glutamic acid kidney diseases elasticity point mutation pedigree site directed mutagenesis secondary protein structure probability epithelial cells x ray crystallography genomes and genes actn4 products actn4 products species human mouse biological mechanism of familial focal segmental glomerulosclerosis-1 summary principal investigator: martin pollak affiliation: harvard university country: usa abstract: mutations in the alpha-actinin-4 gene actn4 cause an autosomal dominant form of focal and segmental glomerulosclerosis (fsgs). viagra online viagra for sale generic Actn4-mediated fsgs is dominant, adult onset, and slowly progressive, suggesting subtle time and stress dependent alterations in podocyte function. viagra for sale generic viagra doesnt work anymore The hypothesis guiding our studies is that dominant, gain-of-function mutations in the actin-binding domain of alpha-actinin-4 leads to an altered actin cytoskeleton, altered mechanical function, and a decreased ability to respond to stress. cheap viagra online no precription in canada buy viagra from usa We will continue our efforts to understand this kidney disease, utilizing new biochemical, cellular, and animal tools that we have developed. http://medicaresupplementspecialists.com/pfz-buy-generic-viagra-100mg-nq/ Buy viagra online australia paypal We aim to: (1) define the effect of mutant alpha-actinin-4 on the biomechanical properties of the actin cytoskeleton and on actin dynamics: we will determine if alpha-actinin-4 mutations act in a gain-of-function manner to alter the structure of the actin filament network and actin dynamics. does viagra and alcohol mix generic viagra online overnight delivery We will determine the effect of alpha-actinin-4 mutations on actin dynamics and polymerization in vitro and in vivo, as well as the effect on the ultrastructure of the actin cytoskeleton. viagra generic discount Viagra vs. viagra side effects We will also examine if the actin and alpha-actinin-4-associated molecule synaptopodin alters the biochemical properties of mutant alpha-actinin-4. buy viagra without prescription is it safe for a 17 year old to take viagra (2) define the downstream effects of mutant alpha-actinin-4 biology on cellular processes: we will determine if actn4-mediated alterations in the cytoskeleton have detrimental cellular consequences. viagra for sale generic viagra side effects diarrhea We will examine the biomechanical properties of mutant cells. how long does viagra daily take to work We will examine if aggregation of alpha-actinin and actin caused by disease-associated mutations has toxic effects on proteasome function. generic viagra online We will also determine if the cytoskeletal changes lead to altered mitochondrial function, increased ros production, and apoptosis. http://vanguard-instruments.com/2015-sales-meeting/img/appicon/mililitres.php?eli=generic-viagra-gv (3) define the role of envirionmental and genetic factors on glomerular function in actn4-mutant disease in vivo: we will stress mice to determine if het. using viagra premature ejaculation viagra online canada المـوديل  
 
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